资阳市疾控中心
发表于 2024-7-18 10:32
20岁女孩患癌，竟牵出一家8口同种病！是什么“谜团”笼罩在这个家族头顶？
<!----><style type="text/css">html{font-size:375%}</style><link href="https://pic.app.jiuquhe.com/static/publish/css/style.css?v=20240712" rel="stylesheet" position="1" data-qf-origin="/static/publish/css/style.css?v=20240712"><!-- 付费贴--> <div class="preview_article "> <!----> <section><section style="outline: 0px; font-size: 16px; letter-spacing: 1px; text-align: unset; text-wrap: wrap; background-color: #ffffff; font-family: system-ui, -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;"><section style="margin-bottom: 10px; outline: 0px; letter-spacing: 0.544px; text-align: left; justify-content: flex-start; display: flex; flex-flow: row;"><section style="padding: 40px 20px 20px; outline: 0px; display: inline-block; width: auto; vertical-align: top; align-self: flex-start; flex: 100 100 0%; height: auto; background-color: rgba(72, 126, 252, 0.09); border-style: solid; border-width: 3px 0px 0px; border-color: #3e54f8;"><section style="outline: 0px; text-align: justify; line-height: 2;"><p style="text-align: center; outline: 0px;"><img class="rich_pages wxw-img js_insertlocalimg" style="outline: 0px; vertical-align: baseline; width: 284px !important; visibility: visible !important;" src="https://pic.app.jiuquhe.com/FqHl7z3g0XxIKKPHgEDQ9lgp5jmt" /></p></section></section></section><section style="margin-top: 10px; margin-bottom: 20px; outline: 0px; letter-spacing: 0.544px; text-align: center; justify-content: center; display: flex; flex-flow: row;"><section style="padding-right: 5px; outline: 0px; display: inline-block; vertical-align: bottom; width: auto; min-width: 5%; flex: 0 0 auto; height: auto; align-self: flex-end;"><section style="margin-top: 3px; margin-bottom: -17px; outline: 0px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row; transform: translate3d(-5px, 0px, 0px); -webkit-transform: translate3d(-5px, 0px, 0px); -moz-transform: translate3d(-5px, 0px, 0px); -o-transform: translate3d(-5px, 0px, 0px);"><section style="padding-right: 2px; padding-left: 2px; outline: 0px; display: inline-block; vertical-align: middle; width: auto; align-self: center; flex: 0 0 0%; height: auto;"><section style="outline: 0px; text-align: center;"><section style="outline: 0px; display: inline-block; vertical-align: top; background-color: #1354de; box-shadow: #c1efe4 0px 0px 0px; line-height: 1; letter-spacing: 0px; width: 5px; height: auto; transform: matrix(1, 0, -0.2, 1, 0, 0);"><section style="outline: 0px; text-align: justify;"><p style="outline: 0px;"> </p></section></section></section></section><section style="padding-right: 2px; padding-left: 2px; outline: 0px; display: inline-block; vertical-align: middle; width: auto; align-self: center; flex: 0 0 0%; height: auto;"><section style="outline: 0px; text-align: center;"><section style="outline: 0px; display: inline-block; vertical-align: top; background-color: #1354de; box-shadow: #c1efe4 0px 0px 0px; line-height: 1; letter-spacing: 0px; width: 5px; height: auto; transform: matrix(1, 0, -0.2, 1, 0, 0);"><section style="outline: 0px; text-align: justify;"><p style="outline: 0px;"> </p></section></section></section></section></section></section><section style="outline: 0px; line-height: 2em;"><section style="outline: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; height: auto; border-bottom: 1px solid #1354de;"><section style="outline: 0px; font-size: 24px; line-height: 1;"><p style="outline: 0px;"><span style="outline: 0px; color: #1354de; font-size: 15px;"><strong style="outline: 0px;">20岁女孩确诊肠癌</strong></span></p><p style="outline: 0px;"><span style="outline: 0px; color: #f9b800;"><strong style="outline: 0px;"><span style="outline: 0px; font-size: 16px;">抽丝剥茧查出家族病</span></strong></span></p></section></section></section><section style="outline: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; height: auto;"><section style="margin-top: 3px; margin-bottom: 10px; outline: 0px; line-height: 0;"><section style="outline: 0px; vertical-align: middle; display: inline-block; line-height: 0; width: 20px; height: auto;"><img class="rich_pages wxw-img __bg_gif" style="outline: 0px; vertical-align: middle; width: 20px !important; visibility: visible !important;" src="https://pic.app.jiuquhe.com/FrQ76YnDsoNYVIaXPMXWPePFSkIX" /></section></section></section></section><section style="outline: 0px; letter-spacing: 0.544px; line-height: 2;"><p style="outline: 0px;"><span style="outline: 0px;">20岁的丽丽（化名）似乎比别人更容易“拉肚子”，稍微吃点生冷刺激的东西，就忍不住要跑厕所，大便经常不成形，还伴随着腹部隐痛。</span></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="outline: 0px;">在当地医院进行肠镜检查后，结果提示她的肠道里长了密密麻麻百余枚息肉，最大的息肉直径超过6cm，治疗颇为棘手。</span></p><p style="text-align: center; outline: 0px;"><img class="rich_pages wxw-img" style="outline: 0px; vertical-align: baseline; visibility: visible !important; width: 677px !important;" src="https://pic.app.jiuquhe.com/FpLDL_BUh5F6hY9vaLjiYqLVVTEK" /></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="outline: 0px;">2024年6月初，丽丽求诊于浙大一院，通过追问病史，说起2016年丽丽的妈妈黄女士（化名）曾在浙大一院结直肠外科做了结直肠腺癌根治切除手术，而今年5月，丽丽的小姨也刚在这里做了同样的手术。</span></p><p style="outline: 0px;"> </p><section style="outline: 0px; margin-bottom: 16px;"><span style="outline: 0px;">三人病情相似，都是肠道内长满密密麻麻上百颗息肉，并且很不幸的是，部分息肉都已经发生了癌变。</span></section><p style="text-align: center; outline: 0px;"><img class="rich_pages wxw-img js_insertlocalimg" style="outline: 0px; vertical-align: baseline; visibility: visible !important; width: 677px !important;" src="https://pic.app.jiuquhe.com/FnKxR-idSEhzgu-Iwo045s1tvFHK" /></p></section><section style="outline: 0px; letter-spacing: 0.544px; display: flex; width: 677px; flex-flow: column;"><section style="outline: 0px; z-index: 1;"><section style="margin-top: 10px; margin-bottom: -25px; outline: 0px; text-align: right; line-height: 0;"><section style="outline: 0px; vertical-align: middle; display: inline-block; line-height: 0; width: 35px; height: auto;"><img class="__bg_gif" style="outline: 0px; vertical-align: middle; width: 35px !important; visibility: visible !important;" src="https://pic.app.jiuquhe.com/FjbwmjgXQbavz9VZsQoYuzZ5G58G" /></section></section></section></section><section style="outline: 0px; letter-spacing: 0.544px; text-align: left; justify-content: flex-start; display: flex; flex-flow: row;"><section style="outline: 0px; display: inline-block; width: 169.25px; vertical-align: top; align-self: flex-start; flex: 0 0 auto; height: auto;"><section style="outline: 0px;"><section style="outline: 0px; border-top: 3px dashed #d1eeff;"></section></section></section></section><section style="margin-top: 10px; margin-bottom: 10px; outline: 0px; letter-spacing: 0.544px; text-align: left; justify-content: flex-start; display: flex; flex-flow: row;"><section style="padding-right: 10px; padding-left: 10px; outline: 0px; display: inline-block; width: 677px; vertical-align: top; align-self: flex-start; flex: 0 0 auto; border-top: 3px dashed #d1eeff; border-bottom: 3px dashed #d1eeff;"><section style="margin-top: -30px; margin-bottom: -20px; outline: 0px; justify-content: flex-start; display: flex; flex-flow: row;"><section style="padding: 50px 20px 40px; outline: 0px; display: inline-block; width: 657px; vertical-align: top; align-self: flex-start; flex: 0 0 auto; border-left: 3px dashed #d1eeff; border-right: 3px dashed #d1eeff; height: auto;"><section style="outline: 0px; text-align: justify; font-size: 15px; line-height: 2;"><p style="outline: 0px;"><span style="font-size: 16px;">“很有可能是家族性腺瘤性息肉病（简称FAP）。”医生建议丽丽接受了APC基因突变的基因检测，结果证实了专家的猜想。</span></p></section></section></section></section></section><section style="margin-bottom: 15px; outline: 0px; letter-spacing: 0.544px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row;"><section style="outline: 0px; display: inline-block; width: 304.641px; vertical-align: top; align-self: flex-start; flex: 0 0 auto; height: auto;"><section style="outline: 0px;"><section style="outline: 0px; border-top: 3px dashed #d1eeff;"></section></section></section></section><section style="outline: 0px; letter-spacing: 0.544px; line-height: 2;"><p style="outline: 0px;"><span style="outline: 0px;">“这是一种少见的<span style="outline: 0px; color: #0052ff;"><strong style="outline: 0px;">常染色体显性遗传病</strong></span>，具有家族遗传性，因为婴幼儿时期并不发病所以往往会被忽略，一般15～25岁开始出现症状，如果不加干预，在35岁前发生癌变的几率在80%~90%，而50岁前癌变的几率则高达100%。”主任医师介绍，浙大一院结直肠外科接诊的家族性<span style="outline: 0px; letter-spacing: 0.578px;">腺瘤性</span>息肉病患者，有的肠道内可多达上千颗息肉状腺瘤，这些息肉在早期通常是良性的，但随着时间推移，部分息肉就会发生恶变，所以要及早筛查，做到早发现、早治疗，别等拖到演变成肠癌才追悔莫及！</span></p></section><section style="margin-top: 10px; margin-bottom: 20px; outline: 0px; letter-spacing: 0.544px; text-align: center; justify-content: center; display: flex; flex-flow: row;"><section style="padding-right: 5px; outline: 0px; display: inline-block; vertical-align: bottom; width: auto; min-width: 5%; flex: 0 0 auto; height: auto; align-self: flex-end;"><section style="margin-top: 3px; margin-bottom: -17px; outline: 0px; text-align: right; justify-content: flex-end; display: flex; flex-flow: row; transform: translate3d(-5px, 0px, 0px); -webkit-transform: translate3d(-5px, 0px, 0px); -moz-transform: translate3d(-5px, 0px, 0px); -o-transform: translate3d(-5px, 0px, 0px);"><section style="padding-right: 2px; padding-left: 2px; outline: 0px; display: inline-block; vertical-align: middle; width: auto; align-self: center; flex: 0 0 0%; height: auto;"><section style="outline: 0px; text-align: center;"><section style="outline: 0px; display: inline-block; vertical-align: top; background-color: #1354de; box-shadow: #c1efe4 0px 0px 0px; line-height: 1; letter-spacing: 0px; width: 5px; height: auto; transform: matrix(1, 0, -0.2, 1, 0, 0);"><section style="outline: 0px; text-align: justify;"><p style="outline: 0px;"> </p></section></section></section></section><section style="padding-right: 2px; padding-left: 2px; outline: 0px; display: inline-block; vertical-align: middle; width: auto; align-self: center; flex: 0 0 0%; height: auto;"><section style="outline: 0px; text-align: center;"><section style="outline: 0px; display: inline-block; vertical-align: top; background-color: #1354de; box-shadow: #c1efe4 0px 0px 0px; line-height: 1; letter-spacing: 0px; width: 5px; height: auto; transform: matrix(1, 0, -0.2, 1, 0, 0);"><section style="outline: 0px; text-align: justify;"><p style="outline: 0px;"> </p></section></section></section></section></section></section><section style="outline: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; height: auto; border-bottom: 1px solid #1354de;"><section style="outline: 0px; font-size: 24px; line-height: 1;"><p style="outline: 0px;"><span style="outline: 0px; color: #1354de; font-size: 15px;"><strong style="outline: 0px;">这病具有强烈的遗传性</strong></span></p><p style="outline: 0px;"><span style="outline: 0px; color: #f9b800;"><strong style="outline: 0px;"><span style="outline: 0px; font-size: 16px;">这个家族至少8人中招</span></strong></span></p></section></section><section style="outline: 0px; display: inline-block; vertical-align: top; width: auto; align-self: flex-start; flex: 0 0 auto; min-width: 5%; height: auto;"><section style="margin-top: 3px; margin-bottom: 10px; outline: 0px; line-height: 0;"><section style="outline: 0px; vertical-align: middle; display: inline-block; line-height: 0; width: 20px; height: auto;"><img class="rich_pages wxw-img __bg_gif" style="outline: 0px; vertical-align: middle; width: 20px !important; visibility: visible !important;" src="https://pic.app.jiuquhe.com/FrQ76YnDsoNYVIaXPMXWPePFSkIX" /></section></section></section></section><section style="outline: 0px; letter-spacing: 0.544px; line-height: 2;"><p style="outline: 0px;"><span style="outline: 0px;">6月中旬，丽丽进行了全大肠切除手术，她目前恢复良好。但故事并没有到此为止。</span></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="outline: 0px;">“我们兄弟姐妹四人，早些年连最基本的肠镜都没有检查过！”丽丽回忆，听她妈妈讲，当时医生就建议黄女士给四个子女都去做下基因检测，查一查是否是家族性腺瘤性息肉病，但是黄女士一方面怕浪费钱，另一方面又怕家里其他人真的查出和她类似的毛病而陷入绝望，没有采纳医生的建议。</span></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="outline: 0px;">2022年，丽丽29岁的亲哥哥军军（化名）查出肠癌，在外院做了手术。在医生建议下，丽丽最终说服了兄弟姐妹及其子女，小姨、小姨的子女做了相关基因检测，结果除了已经过世的老人、整个家族中已知的至少有8人中招FAP！</span></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="outline: 0px; font-size: 15px;"><img class="rich_pages wxw-img js_insertlocalimg" style="outline: 0px; letter-spacing: 0.578px; text-align: center; vertical-align: baseline; visibility: visible !important; width: 677px !important;" src="https://pic.app.jiuquhe.com/Fp_PYwd16hcNokRZBKVlWwTLt4X2" /></span></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="outline: 0px;">幸运的是，得知情况较早的军军两个子女，已经开始增加肠镜筛查的频次，尽早启动了干预和预防措施，避免或延缓肠癌的发生。至此，笼罩在这个家族头顶的“肠癌”谜团终于解开。</span></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="color: #0080ff;"><strong>如何发现FAP？</strong></span><span style="outline: 0px;">专家介绍，它的早期症状不明显，常见的症状有腹泻、腹痛、便血，很容易被忽视。往往是疾病发展到较严重的程度——出现明显的黏液血便、里急后重甚至肠梗阻， 有时位于直肠下端的较大的息肉甚至会脱出肛外，呈暗红色、乳头状肿瘤，才会引起重视。患者还可能伴随有贫血、体重减轻等症状。</span></p><p style="text-align: center; outline: 0px;"><img class="rich_pages wxw-img js_insertlocalimg" style="outline: 0px; vertical-align: baseline; visibility: visible !important; width: 677px !important;" src="https://pic.app.jiuquhe.com/Fj3076yagjWUwnDCxAzHEo5tgGI_" /></p><p style="outline: 0px;"> </p></section><section style="outline: 0px; letter-spacing: 0.544px; display: flex; width: 677px; flex-flow: column;"><section style="outline: 0px; z-index: 1;"><section style="margin-bottom: -6px; outline: 0px; text-align: left; justify-content: flex-start; display: flex; flex-flow: row;"><section style="outline: 0px; display: inline-block; vertical-align: middle; width: auto; align-self: center; flex: 0 0 auto; min-width: 5%; height: auto;"><section style="outline: 0px; text-align: justify; font-size: 18px; color: #238dff; letter-spacing: 2px;"><p style="outline: 0px;"><strong style="outline: 0px;">专家强调</strong></p></section></section><section style="padding-right: 10px; padding-left: 10px; outline: 0px; display: inline-block; vertical-align: middle; width: auto; align-self: center; flex: 0 0 0%; height: auto; line-height: 0;"><section style="outline: 0px; transform: rotateZ(45deg); -webkit-transform: rotateZ(45deg); -moz-transform: rotateZ(45deg); -o-transform: rotateZ(45deg);"><section style="outline: 0px; text-align: center;"><section style="outline: 0px; display: inline-block; width: 8px; height: 8px; vertical-align: top; overflow: hidden; background-color: #ffc551;"></section></section></section></section><section style="outline: 0px; display: inline-block; vertical-align: middle; width: auto; align-self: center; flex: 100 100 0%; height: auto;"><section style="outline: 0px;"><section style="outline: 0px; border-top: 3px dashed #25b4aa;"></section></section></section><section style="padding-left: 10px; outline: 0px; display: inline-block; vertical-align: middle; width: auto; min-width: 5%; flex: 0 0 auto; height: auto; align-self: center;"></section></section></section></section><section style="outline: 0px; letter-spacing: 0.544px; line-height: 2em;"><section style="margin-bottom: 5px; outline: 0px; text-align: left; justify-content: flex-start; display: flex; flex-flow: row;"><section style="padding: 20px; outline: 0px; display: inline-block; width: 677px; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-color: #fafdff; border: 1px solid #d1eeff;"><section style="outline: 0px; text-align: justify; font-size: 15px; line-height: 2;"><p style="outline: 0px;"><span style="font-size: 16px;">FAP是一种显性遗传病，这意味着如果父母中有一方患有FAP，子女有50%的概率遗传这种病。如果家族中有患此病的亲人，直系亲属即属于高危人群，一方面可以通过基因检测确定是否携带导致FAP的突变基因，了解自身患病风险，指导生育选择；另一方面提倡在20岁左右，甚至更早就要进行胃肠镜检查，配合使用非甾体类抗炎药物延缓息肉病的发生，一经发现息肉开始弥漫性生长，最好是做预防性手术切除，以防癌变。决不能任由它发展！ </span></p></section></section></section></section><section style="outline: 0px; letter-spacing: 0.544px; line-height: 2;"><p style="text-align: center; outline: 0px;"><img class="rich_pages wxw-img js_insertlocalimg" style="outline: 0px; vertical-align: baseline; visibility: visible !important; width: 677px !important;" src="https://pic.app.jiuquhe.com/FgEguxbxvj8uIbsPhumPPNwIwbab" /></p><p style="outline: 0px;"> </p><p style="outline: 0px;"><span style="outline: 0px;">结直肠癌是一个“缓慢过程”，从肠息肉到肠癌变有4步，是一个相对漫长的过程，即：小息肉→大息肉→不典型增生→肠癌。“发现它，监测它，实在不行切了它。”专家强烈呼吁把肠镜纳入个人必要的体检项目，这是医学进步给我们每一个人发现癌症、治疗癌症的生存机会。</span></p></section></section><p style="text-align: center; outline: 0px; text-wrap: wrap; background-color: #ffffff; letter-spacing: 0.578px; font-family: system-ui, -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;"> </p><p style="text-align: center; outline: 0px; text-wrap: wrap; background-color: #ffffff; letter-spacing: 0.578px; font-family: system-ui, -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;"> </p><section style="letter-spacing: 0.544px; text-wrap: wrap; background-color: #ffffff; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif;"><section style="outline: 0px;"><section style="outline: 0px; height: 0px; overflow: hidden;"></section></section></section><p style="display: none;"> </p><section style="margin-bottom: 0px; text-wrap: wrap; outline: 0px; font-size: 16px; letter-spacing: 0.578px; background-color: #ffffff; text-align: center; color: #222222; visibility: visible;"><section style="outline: 0px; text-align: left;"><span style="outline: 0px; font-size: 12px;"><span style="font-size: 12px; outline: 0px; font-family: -apple-system, BlinkMacSystemFont, Arial, sans-serif; letter-spacing: 0.544px; color: #888888; caret-color: red;">来源 | <span style="outline: 0px; color: #888888; font-family: system-ui, -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif; letter-spacing: 0.578px; text-align: center; text-wrap: wrap; background-color: #ffffff;">浙大一院</span>、沧州</span><span style="font-size: 12px; outline: 0px; text-align: center; letter-spacing: 0.034em; color: #888888;">疾控</span></span></section><section style="outline: 0px; font-family: system-ui, -apple-system, system-ui, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif; 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如约而至
发表于 2024-7-18 10:43
定期体检
阳光明睸
发表于 2024-7-18 14:11
我的吓人
平淡李
发表于 2024-7-18 17:02
有点吓人啊
霸道[SHEN.X.S)
发表于 2024-7-18 20:27
这个太恐怖了
吴素先
发表于 2024-7-18 20:41
谢谢告知
无所畏惧
发表于 2024-7-18 21:13
要能治疗癌症才是王道啊
风雪夜归人
发表于 2024-7-20 18:10
这个太恐怖了
风雪夜归人
发表于 2024-7-20 18:10
谢谢分享
落羽神恋曲
发表于 2024-7-20 23:22
定期体检